Oh yay! I'm not overly knowledgeable but I loathe floppy single-issue comics with a passion, so unless I really adore a certain series and get the shiny hardcover collection, all my stuff is digital through Comixology. You can read them on your computer through their site, or dl the app for your mobile or tablet. (they all have the feature to read from panel to panel instead of page to page, so size isn't that big of an issue).

Comixology also tends to have frequent sales, so I like to wishlist most things and check periodically. Subscribing to series gets expensive fast, so unless I absolutely have to read/keep up with something, or it's a smaller thing I really want to support, I wait for the collected trades. There's usually a bit of a discount, especially if you pre-order them/wait for a sale.

I know there's a Marvel subscription (through Marvel) where you get access to a huge part of their backlog, but I don't know how much of a delay there is on those.